TLR3

TLR3
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Identifiants
Aliases	TLR3, CD283
IDs externes	OMIM: 603029 MGI: 2156367 HomoloGene: 20696 GeneCards: TLR3
Position du gène (Homme)
Chr.	Chromosome 4 humain
Fin	186,088,073 bp
Position du gène (Souris)
Chr.	Chromosome 8 (souris)
Fin	45,864,117 bp
Expression génétique
	Fortement exprimé dans
	muqueuse jéjunale; ; palpebral conjunctiva; ; placenta; ; rectum; ; sperme; ; duodénum; ; vésicule biliaire; ; tendon calcanéen; ; pancreatic epithelial cell; ; pancreatic ductal cell;
	Fortement exprimé dans
	conjunctival fornix; ; strie vasculaire; ; secondary oocyte; ; Jéjunum; ; utricle; ; valve aortique; ; duodénum; ; Cellule de Paneth; ; gros intestin; ; côlon;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; identical protein binding; liaison ARN; liaison ARN double brin; transmembrane signaling receptor activity; signaling receptor activity;
Composant cellulaire	cytoplasme; integral component of membrane; endosome; membrane du réticulum endoplasmique; membrane; Golgi membrane; integral component of plasma membrane; intracellulaire; surface cellulaire; lysosomal membrane; early endosome; réticulum endoplasmique; endolysosome membrane; endosome membrane; milieu extracellulaire; matrice extracellulaire;
Processus biologique	positive regulation of interferon-beta production; response to dsRNA; réponse de défense; positive regulation of toll-like receptor signaling pathway; positive regulation of protein phosphorylation; male gonad development; positive regulation of inflammatory response; positive regulation of interleukin-12 production; positive regulation of type III interferon production; cellular response to interferon-beta; response to exogenous dsRNA; negative regulation of osteoclast differentiation; positive regulation of cytokine production; processus du système immunitaire; response to virus; activation of NF-kappaB-inducing kinase activity; I-kappaB phosphorylation; positive regulation of JNK cascade; hyperosmotic response; cellular response to dsRNA; regulation of dendritic cell cytokine production; microglial cell activation; toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; microglial cell activation involved in immune response; positive regulation of gene expression; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; defense response to virus; necroptotic signaling pathway; positive regulation of interleukin-8 production; cellular response to exogenous dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; cellular response to interferon-gamma; positive regulation of chemokine production; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; detection of virus; réponse inflammatoire; système immunitaire inné; I-kappaB kinase/NF-kappaB signaling; toll-like receptor 3 signaling pathway; positive regulation of type I interferon production; MyD88-independent toll-like receptor signaling pathway; transduction de signal; positive regulation of transcription by RNA polymerase II; Nécrose programmée; apoptotic signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; extrinsic apoptotic signaling pathway; positive regulation of angiogenesis; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologues
	7098
	142980
	ENSG00000164342
	ENSMUSG00000031639
	O15455
	Q99MB1
	NM_003265
	NM_126166; NM_001357316; NM_001357317
	NP_003256
	NP_569054; NP_001344245; NP_001344246
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le TLR3 (ou CD283) est une protéine de type récepteur de type Toll intervenant dans l'immunité inné. Il s'agit également d'une cluster de différenciation. Son gène est le TLR3 situé sur le chromosome 4 humain.

Rôles[modifier | modifier le code]

Il participe à l'immunité antivirale par l'intermédiaire de l'interféron de type 2^[5].

En médecine[modifier | modifier le code]

Les porteurs de certains variants du gène ont une plus grande susceptibilité à une atteinte virale^[6].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000164342 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000031639 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Negishi H, Osawa T, Ogami K et al. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity, Proc Natl Acad Sci U S A, 2008;105:20446–20451
↑ Gorbea C, Makar KA, Pauschinger M et al. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy, J Biol Chem, 2010;285:23208–23223

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000164342 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000031639 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Negishi_2008-5] Negishi H, Osawa T, Ogami K et al. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity, Proc Natl Acad Sci U S A, 2008;105:20446–20451

[Gorbea_2010-6] Gorbea C, Makar KA, Pauschinger M et al. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy, J Biol Chem, 2010;285:23208–23223

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